New Breath Test May Be Able to Detect a Variety of Cancers

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Imagine being able to detect cancer simply by breathing into a device similar to a breathalyzer.
It could become a reality, as a new clinical trial will soon evaluate this technology.
Researchers say the new device has the potential to detect multiple types of cancer.
It could offer an early detection method that would allow for earlier treatments.
Researchers from the Cancer Research UK Cambridge Centre are conducting the trial with Owlstone Medical, which developed the Breath Biopsy technology.
“The potential to detect a cancer early through a simple, noninvasive breath test is really exciting,” said Dr. Nicholas Rohs, an assistant professor of hematology and oncology in thoracic medical oncology at The Blavatnik Family – Chelsea Medical Center at Mount Sinai in New York.
“The earlier we discover a cancer, the more likely we can cure it,” he told Healthline.
He says that although the technology still has a long way to go, it could be a “powerful clinical tool” if refined.
A cancer breath test may sound like something new, but it’s been studied in the past. It’s also used to diagnose gastrointestinal conditions.
In addition, we already know that people with kidney or liver failure, for example, have changes in the scent of their breath, Rohs notes.
How the test works
Here’s how the test works.
People breathe into a device containing the Breath Biopsy technology, which detects volatile organic compounds (VOCs).
These are odorous molecules released in our breath, which develop when cells metabolize.
When a cell’s metabolism is altered, as it does with cancer, the cells can release a different VOC pattern. The test is designed to identify patterns associated with different forms of the disease.
“The idea is to detect volatiles which may have signatures specific to different cancer types,” Dr. Rebecca Fitzgerald, the lead trial investigator at the Cancer Research UK Cambridge Centre, told Healthline.
Some evidence supports that different types of cancers have different VOC patterns.
“The metabolism of different sorts of cancer cells is different according to the mutations that perturb cells in specific ways,” Fitzgerald explained.
Hopefully, the researchers can correlate different VOC patterns to specific types of cancers, she adds.
A variety of participants
The two-year trial will draw upon samples from 1,500 people.
This will include those without cancer, which will act as a control to better analyze VOCs in people who do have cancer.
The trial will begin with people thought to have esophageal and stomach cancers and then expand to prostate, kidney, bladder, liver, and pancreatic cancers.
Participants suspected of having cancer will be referred to Addenbrooke’s Hospital in Cambridge and will be given the breath test before other diagnostic tests.
Samples from people who have a cancer diagnosis will be compared to those who don’t develop the disease.
Cancer’s unique biology
Rohs says it makes sense that cancers of the neck, stomach, esophagus, or lung may be more accurately detected with a breath test.
Lots of what the tests pick up are organic compounds being released from the bloodstream into the lungs.
“Each type of cancer has a unique biology and can release different compounds into our body, so we need more studies to see which type of tumor may be best detected by this type of test,” he said. “Therefore, the best cancers to utilize this test will be ones that release the most unique ‘chemical fingerprint.’”
The level and type of VOCs released can vary between both healthy and sick individuals. A variety of factors can also alter them, such as diet, smoking, and other medical conditions, Rohs notes.
“Figuring out which VOCs are clinically useful and being able to minimize the other ‘background noise’ to provide us reliable results will be one of the most challenging hurdles to overcome,” he added.
The test wouldn’t necessarily replace traditional diagnostic tests, Fitzgerald says. Ideally, it will be used in general practices to determine if patients need further testing.
Dr. Brendon Stiles, a thoracic surgeon at Weill Cornell Medicine Center in New York, agrees that the breath test wouldn’t replace other early detection methods but could be helpful as an adjunct test.