Is It Safe to Give People with Alzheimer’s Medical Marijuana?

Some states are going ahead with plans to allow the use of marijuana by people with Alzheimer’s.
Health researchers say that might be risky — despite evidence there could be some benefits to certain people in some circumstances.
The problem with that evidence, they say, is that there just isn’t enough of it.
Last week, officials in Minnesota announced they would add Alzheimer’s disease to the list of conditions for which people can purchase medical marijuana.
If a resident has been diagnosed with Alzheimer’s, they would be allowed under state law to purchase medical marijuana from a licensed manufacturer starting August 1.
Alzheimer’s would join 13 other approved conditions, ranging from irritable bowel disease and intractable pain, to HIV and some cancers.
At least 13 other states already allow people with Alzheimer’s to use medical marijuana, according to the cannabis website Leafly.
Pennsylvania, one state that doesn’t allow it, approved a new way to speed up the addition of new conditions to its medical marijuana list last Tuesday.
Does marijuana help?
The expansion of access to marijuana for people with Alzheimer’s comes amid a lot of unknowns over the effects of pot on the symptoms and quality of life for people with the disease.
Researchers see the potential for benefits in some cases, but they issue an abundance of caution due to possible unforeseen risks.
Jan Malcolm, the Minnesota health commissioner, acknowledged as much in announcing the addition of Alzheimer’s to the approved list.
“Any policy decisions about cannabis are difficult due to the relative lack of published scientific evidence,” she said.
However, she pointed to evidence that medical marijuana can lead to improvements in patients’ mood, sleeping, and behavior as justification.
Alzheimer’s advocacy groups have acknowledged those benefits but noted the studies are limited so far.
“Symptoms such as agitation and aggression could in theory be counteracted by the effects of cannabis or its components,” according to the United Kingdom’s Alzheimer’s Society.
“However, scientific reviews have found that the trials and studies so far have generally been small or of low quality (see here and here for references), making it difficult to come to an informed conclusion.”
In a statement to Healthline, the Alzheimer’s Association in the United States said that “marijuana is, essentially, an untested drug in Alzheimer’s disease.”
“Its potential effectiveness and safety profile have not been thoroughly evaluated in clinical trials in people with (or at risk for) Alzheimer’s,” the organization added. “The Alzheimer’s Association believes that more research in this area is needed.”
It seems the research is intriguing enough for some states to allow marijuana use for managing Alzheimer’s symptoms — in some cases, with prior doctor approval.
“I cannot imagine that it would be harmful at all, other than being a little freaky, as long as it’s used safely,” Gary Wenk, a behavioral neuroscience professor at The Ohio State University who has studied the influence of marijuana on Alzheimer’s, told Healthline.
“When high, they’d be more likely to get up and move around, but it could also increase their appetite, which could help. And a lot of older people have a lot of aches and pains — one thing marijuana is clearly good for is inflammation and pain,” he added.
Would he recommend someone with Alzheimer’s try it?
There are a lot of question marks, Wenk said, and those are complicated by the fact that, as an illegal drug under federal law, marijuana’s effects can’t be tested on humans.“But what we know for certain is that it is not a treatment for Alzheimer’s. I wouldn’t recommend giving it at all,” he said.Wenk has served on Ohio’s Governor’s Medical Marijuana Advisory Committee, which advises on such regulations in the state.
He said he gets a lot of emails from spouses or children of people with Alzheimer’s saying they’ve read marijuana could be good for their loved one.
“And I’m the one to blame for that,” Wenk said, citing an article he wrote in 2016 for Psychology Today. “But I don’t know how frightening it would be for someone to be demented and then be made high without their knowledge.”